Pseudoporphyria secondary to renal failure

• Main Authors: Lilianna Kulczycka-Siennicka, Anna Woźniacka, Remigiusz Szumiński, Agnieszka Żebrowska
• Format: Article
• Language: English
• Published: Termedia Publishing House 2017-04-01
• Series: Przegląd Dermatologiczny
• Subjects: dialysis therapy; pseudoporphyria; chloroquine; renal failure; porphyria cutanea tarda
• Online Access: https://www.termedia.pl/Pseudoporphyria-secondary-to-renal-failure,56,29863,1,1.html

Introduction . Pseudoporphyria is a rare disease associated with chronic renal failure. Symptoms of pseudoporphyria may develop in response to UV exposure and medications. The literature reports cases of pseudoporphyria in patients infected with hepatis C virus, HIV and undergoing dialysis therapy. Objective . Presentation of the case of a patient with pseudoporphyria and uraemic pruritus, and overview of therapeutic management. Case report . A 64-year-old male patient, who had been on dialysis for chronic renal failure secondary to type 2 diabetes for the past 11 years, presented with tense bullae located on sun-exposed skin which had persisted for the previous 5 months. The patient was diagnosed with pseudoporphyria, and treatment was prescribed including N-acetylcysteine, chloroquine, paroxetine and mianserin. An improvement in the patient’s clinical condition and a regression of pruritus were achieved. Conclusions . Patients with renal failure may develop symptoms of pseudoporphyria requiring differentiation from porphyria cutanea tarda.