Impaired baroreflex function in mice overexpressing alpha-synuclein

Impaired baroreflex function in mice overexpressing alpha-synuclein

Cardiovascular autonomic dysfunction, such as orthostatic hypotension consequent to baroreflex failure and cardiac sympathetic denervation, is frequently observed in the synucleinopathy Parkinson’s disease (PD). In the present study, the baroreceptor reflex was assessed in mice overexpressing human...

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Bibliographic Details
Main Authors: Sheila eFleming, Maria C. Jordan, Caitlin K. Mulligan, Eliezer eMasliah, John G. Holden, Ronald W. Millard, Marie-Francoise eChesselet, Kenneth P. Roos
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Neurology
Subjects:
alpha-Synuclein
Baroreflex
Parkinson’s disease
mouse model
orthostatic hypotension
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00103/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00103/full

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