A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)

SUMMARY PRDM14 functions in embryonic stem cell (ESC) maintenance to promote the expression of pluripotency-associated genes while suppressing differentiation genes. Expression of PRDM14 is tightly regulated and typically limited to ESCs and primordial germ cells; however, aberrant expression is ass...

Full description

Bibliographic Details
Main Authors: Brandi L. Carofino, Bernard Ayanga, Monica J. Justice
Format: Article
Language:English
Published: The Company of Biologists 2013-11-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/6/1494

Similar Items

Similar Items