Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells.

Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells.

Epstein-Barr virus (EBV) is a human herpesvirus associated with B-cell and epithelial cell malignancies. EBV lytically infects normal differentiated oral epithelial cells, where it causes a tongue lesion known as oral hairy leukoplakia (OHL) in immunosuppressed patients. However, the cellular mechan...

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Main Authors: Dhananjay M Nawandar, Anqi Wang, Kathleen Makielski, Denis Lee, Shidong Ma, Elizabeth Barlow, Jessica Reusch, Ru Jiang, Coral K Wille, Deborah Greenspan, John S Greenspan, Janet E Mertz, Lindsey Hutt-Fletcher, Eric C Johannsen, Paul F Lambert, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4592227?pdf=render

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