Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
Tau, an intrinsically disordered axonal protein, binds to and regulates microtubule dynamics. Here, the authors use SAXS and electron microscopy to examine the architectures of microtubule bundles, including those mimicking microtubule fascicles in the axon initial segment.
Main Authors: | Peter J. Chung, Chaeyeon Song, Joanna Deek, Herbert P. Miller, Youli Li, Myung Chul Choi, Leslie Wilson, Stuart C. Feinstein, Cyrus R. Safinya |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12278 |
Similar Items
-
Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons.
by: Ines Hahn, et al.
Published: (2021-07-01) -
The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology
by: Ines Hahn, et al.
Published: (2019-11-01) -
Molecular Interaction of Tau and Microtubule
by: Yi-Chen Yen, et al.
Published: (2002) -
Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
by: Amayra Hernández-Vega, et al.
Published: (2017-09-01) -
The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila.
by: Jason E Duncan, et al.
Published: (2013-01-01)