Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment

Tau, an intrinsically disordered axonal protein, binds to and regulates microtubule dynamics. Here, the authors use SAXS and electron microscopy to examine the architectures of microtubule bundles, including those mimicking microtubule fascicles in the axon initial segment.

Bibliographic Details
Main Authors:	Peter J. Chung, Chaeyeon Song, Joanna Deek, Herbert P. Miller, Youli Li, Myung Chul Choi, Leslie Wilson, Stuart C. Feinstein, Cyrus R. Safinya
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12278

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spelling	doaj-17af19a67bf1441cbac6e6ba5dbdf4b42021-05-11T11:03:29ZengNature Publishing GroupNature Communications2041-17232016-07-01711910.1038/ncomms12278Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segmentPeter J. Chung0Chaeyeon Song1Joanna Deek2Herbert P. Miller3Youli Li4Myung Chul Choi5Leslie Wilson6Stuart C. Feinstein7Cyrus R. Safinya8Materials Department, Physics Department, and Developmental Biology Department, Molecular, Cellular, University of CaliforniaMaterials Department, Physics Department, and Developmental Biology Department, Molecular, Cellular, University of CaliforniaChemistry and Biochemistry Department, University of Californiaand Developmental Biology Department, Neuroscience Research Institute and Molecular, Cellular, University of CaliforniaMaterials Research Laboratory, University of CaliforniaDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)and Developmental Biology Department, Neuroscience Research Institute and Molecular, Cellular, University of Californiaand Developmental Biology Department, Neuroscience Research Institute and Molecular, Cellular, University of CaliforniaMaterials Department, Physics Department, and Developmental Biology Department, Molecular, Cellular, University of CaliforniaTau, an intrinsically disordered axonal protein, binds to and regulates microtubule dynamics. Here, the authors use SAXS and electron microscopy to examine the architectures of microtubule bundles, including those mimicking microtubule fascicles in the axon initial segment.https://doi.org/10.1038/ncomms12278
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peter J. Chung Chaeyeon Song Joanna Deek Herbert P. Miller Youli Li Myung Chul Choi Leslie Wilson Stuart C. Feinstein Cyrus R. Safinya
spellingShingle	Peter J. Chung Chaeyeon Song Joanna Deek Herbert P. Miller Youli Li Myung Chul Choi Leslie Wilson Stuart C. Feinstein Cyrus R. Safinya Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment Nature Communications
author_facet	Peter J. Chung Chaeyeon Song Joanna Deek Herbert P. Miller Youli Li Myung Chul Choi Leslie Wilson Stuart C. Feinstein Cyrus R. Safinya
author_sort	Peter J. Chung
title	Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
title_short	Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
title_full	Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
title_fullStr	Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
title_full_unstemmed	Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
title_sort	tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-07-01
description	Tau, an intrinsically disordered axonal protein, binds to and regulates microtubule dynamics. Here, the authors use SAXS and electron microscopy to examine the architectures of microtubule bundles, including those mimicking microtubule fascicles in the axon initial segment.
url	https://doi.org/10.1038/ncomms12278
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Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment

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