Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice

Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice

Forced expression of insulin-like growth factor binding proteins (IGFBPs) in transgenic mice has clearly revealed inhibitory effects on somatic growth. However, by this approach, it cannot be solved if or how IGFBPs rule insulin-like growth factor (IGF)-dependent growth under normal conditions. In o...

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Bibliographic Details
Main Authors: Michael Walz, Luong Chau, Christina Walz, Mandy Sawitzky, Daniela Ohde, Julia Brenmoehl, Armin Tuchscherer, Martina Langhammer, Friedrich Metzger, Christine Höflich, Andreas Hoeflich
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
longitudinal study
IGFBP
mouse models
Online Access:https://www.mdpi.com/2073-4409/9/6/1516

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