The Incidence, Characteristics, and Use of Suspected Nephrotoxic Drugs in Elderly Patients with Community-Acquired Acute Kidney Injury

• Main Authors: Hu W, Lian X, Lin J, Chen Y, Wu Y, Liu W, Yu F, Hao W
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-01-01
• Series: Clinical Interventions in Aging
• Subjects: acute kidney injury; community-acquired acute kidney injury; elderly; prognosis; nephrotoxic drug
• Online Access: https://www.dovepress.com/the-incidence-characteristics-and-use-of-suspected-nephrotoxic-drugs-i-peer-reviewed-article-CIA

Wenxue Hu,* Xingji Lian,* Jieshan Lin, Yuanhan Chen, Yanhua Wu, Wei Liu, Feng Yu, Wenke Hao Department of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenke HaoDepartment of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, 106th, Zhongshan Road II, Guangzhou 510080, People’s Republic of ChinaTel + ± 8620-83827812-70811Email [e-mail]: Acute kidney injury (AKI) is a major health problem with poor prognosis. However, little is known about elderly community-acquired-AKI (CA-AKI). This study aimed to investigate the incidence, clinical characteristics, outcomes and use of suspected nephrotoxic medications after CA-AKI in the elderly.Materials and Methods: A total of 36,445 patients aged over 60 years were recruited from 2013 to 2016. Through an electronic database, we collected the demographic and medical history data, and admission lab results from all patients.Results: A total of 2371 patients with CA-AKI were identified. The incidence of CA-AKI was 26.03% in the elderly. The proportion of CA-AKI patients with chronic comorbidities and Charlson comorbidity index score were higher than that of non-AKI patients. After CA-AKI, the proportions of exposure to non-steroidal anti-inflammatory drugs (NSAIDs), iodine contrast agent, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) were significantly decreased (p < 0.001). However, the proportion of other possible nephrotoxic drugs (including aminoglycosides, glycopeptide antibiotics, antifungal agents, beta lactam antibiotics, diuretic, ferralia, adrenergic receptor agonists and drugs for cardiac insufficiency therapy) still increased after CA-AKI (p < 0.001). Compared with non-AKI patients, CA-AKI patients had higher percentage of cardiogenic shock, multiple organ failure, transferring to intensive care unit, cardio-pulmonary resuscitation, hemodialysis, and mortality (p < 0.001). Moreover, CA-AKI patients had worse prognosis when more kinds of suspected nephrotoxic drugs were used (p < 0.001).Conclusion: The incidence of CA-AKI in the elderly was high, with more complex chronic complications and poor clinical outcomes. The use of most suspected nephrotoxic drugs still increased and was associated with worse prognosis after CA-AKI.Keywords: acute kidney injury, community-acquired acute kidney injury, elderly, prognosis, nephrotoxic drug