Non-invasive ventilation in amyotrophic lateral sclerosis

Non-invasive ventilation in amyotrophic lateral sclerosis

Non-invasive ventilation (NIV) has become an important cornerstone of symptomatic treatment in amyotrophic lateral sclerosis (ALS), improving survival and quality of life. In this review, we summarize the most important recent developments and insights, including evidence of efficacy, indication cri...

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Main Authors: Johannes Dorst, Albert C. Ludolph
Format: Article
Language:English
Published: SAGE Publishing 2019-06-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/1756286419857040
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spelling doaj-1782b652021c469fab4b4bc418cb89a72020-11-25T03:19:21ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642019-06-011210.1177/1756286419857040Non-invasive ventilation in amyotrophic lateral sclerosisJohannes DorstAlbert C. LudolphNon-invasive ventilation (NIV) has become an important cornerstone of symptomatic treatment in amyotrophic lateral sclerosis (ALS), improving survival and quality of life. In this review, we summarize the most important recent developments and insights, including evidence of efficacy, indication criteria and time of initiation, ventilation parameters and adaptation strategies, treatment of complicating factors, transition from NIV to invasive ventilation, termination of NIV and end-of-life management. Recent publications have questioned former conventions and guideline recommendations, especially with regard to timing and prognostic factors; therefore, a fresh look and re-evaluation of current evidence is needed.https://doi.org/10.1177/1756286419857040
collection DOAJ
language English
format Article
sources DOAJ
author Johannes Dorst
Albert C. Ludolph
spellingShingle Johannes Dorst
Albert C. Ludolph
Non-invasive ventilation in amyotrophic lateral sclerosis
Therapeutic Advances in Neurological Disorders
author_facet Johannes Dorst
Albert C. Ludolph
author_sort Johannes Dorst
title Non-invasive ventilation in amyotrophic lateral sclerosis
title_short Non-invasive ventilation in amyotrophic lateral sclerosis
title_full Non-invasive ventilation in amyotrophic lateral sclerosis
title_fullStr Non-invasive ventilation in amyotrophic lateral sclerosis
title_full_unstemmed Non-invasive ventilation in amyotrophic lateral sclerosis
title_sort non-invasive ventilation in amyotrophic lateral sclerosis
publisher SAGE Publishing
series Therapeutic Advances in Neurological Disorders
issn 1756-2864
publishDate 2019-06-01
description Non-invasive ventilation (NIV) has become an important cornerstone of symptomatic treatment in amyotrophic lateral sclerosis (ALS), improving survival and quality of life. In this review, we summarize the most important recent developments and insights, including evidence of efficacy, indication criteria and time of initiation, ventilation parameters and adaptation strategies, treatment of complicating factors, transition from NIV to invasive ventilation, termination of NIV and end-of-life management. Recent publications have questioned former conventions and guideline recommendations, especially with regard to timing and prognostic factors; therefore, a fresh look and re-evaluation of current evidence is needed.
url https://doi.org/10.1177/1756286419857040
work_keys_str_mv AT johannesdorst noninvasiveventilationinamyotrophiclateralsclerosis
AT albertcludolph noninvasiveventilationinamyotrophiclateralsclerosis
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