High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake translate into reduced protein O-GlcNAcylation, which promote...

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Bibliographic Details
Main Authors: Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Eugenio Barone, Marzia Perluigi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Francesco Bellanti, Matteo Spinelli, Francesca Natale, Salvatore Fusco, Claudio Grassi, Fabio Di Domenico
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
high-fat diet
brain insulin resistance
neurodegeneration
protein O-GlcNAcylation
mitochondria
Online Access:https://www.mdpi.com/1422-0067/22/7/3746

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