Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice

Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice

Icosabutate is a structurally engineered eicosapentaenoic acid derivative under development for nonalcoholic steatohepatitis (NASH). In this study, we investigated the absorption and distribution properties of icosabutate in relation to liver targeting and used rodents to evaluate the effects of ico...

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Bibliographic Details
Main Authors:	Anita M. van denHoek, Elsbet J. Pieterman, José W. van derHoorn, Marta Iruarrizaga‐Lejarreta, Cristina Alonso, Lars Verschuren, Tore Skjæret, Hans M.G. Princen, David A. Fraser
Format:	Article
Language:	English
Published:	Wiley 2020-02-01
Series:	Hepatology Communications
Online Access:	https://doi.org/10.1002/hep4.1453

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