Associations of intercellular adhesion molecule‐1 rs5498 polymorphism with ischemic stroke: A meta‐analysis

• Main Authors: Hua Gao, Xinhua Zhang
• Format: Article
• Language: English
• Published: Wiley 2019-06-01
• Series: Molecular Genetics & Genomic Medicine
• Subjects: intercellular adhesion molecule‐1 (ICAM‐1); ischemic stroke (IS); meta‐analysis; polymorphisms
• Online Access: https://doi.org/10.1002/mgg3.643

Abstract Background Recently, associations between intercellular adhesion molecule‐1 (ICAM‐1) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta‐analysis was performed to better assess the relationship between ICAM‐1rs5498 polymorphism and IS. Methods PubMed, Medline, Embase, and CNKI were searched for eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate associations between ICAM‐1 rs5498 polymorphism and IS. Results Totally 16 studies with 2,596 cases and 11,800 controls were analyzed. A significant association with IS was observed for rs5498 polymorphism in GG versus AA + AG (recessive model, p = 0.009, OR = 1.62, 95% CI 1.13–2.32, I2 = 76%) in overall population. Further subgroup analyses showed that rs5498 polymorphism was significantly associated with IS in Caucasians in AA versus AG + GG (dominant model, p = 0.03, OR = 0.52, 95% CI 0.29–0.95, I2 = 72%), GG versus AA + AG (recessive model, p < 0.0001, OR = 2.98, 95% CI 2.05–4.31, I2 = 19%), and A versus G (allele model, p = 0.005, OR = 0.50, 95% CI 0.31–0.81, I2 = 81%). However, no any positive findings were detected for Asians. Conclusions Our findings indicated that rs5498 polymorphism was significantly associated with individual susceptibility to IS in Caucasians, but not in Asians.