Effect of sputum suction by bronchofiberoscope combined with routine anti-infective therapy on lung function and inflammatory state in patients with severe lung infection
Objective: To analyze the effect of sputum suction by bronchofiberoscope combined with routine anti-infective therapy on lung function and inflammatory state in patients with severe lung infection. Methods: A total of 52 patients with severe lung infection who received treatment in our hospital f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-07-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201613/13.pdf |
| Summary: | Objective: To analyze the effect of sputum suction by bronchofiberoscope combined with
routine anti-infective therapy on lung function and inflammatory state in patients with severe
lung infection. Methods: A total of 52 patients with severe lung infection who received
treatment in our hospital from January 2015 to December 2015 were selected as research
subjects and were divided into observation group 26 cases and control group 26 cases
according to different treatment methods. Differences in levels of lung function indexes, serum
inflammation-related factors, disease severity-related indexes, JNK/SAPK and TLR2/NF-κB
signaling pathways were compared between two groups. Results: FEV1, MMV, MMEF, FRC
and TLC values of observation group after treatment were higher than those of control group
(P<0.05); serum PAF, MIP-1毩, sTREM-1 and PCT values of observation group were lower
than those of control group while APN value was higher than that of control group (P<0.05);
serum ACE, NO, ET-1, SP-A and HMGB1 values of observation group were lower than those
of control group while CC16 and ChE values were higher than those of control group (P<0.05);
JNK, SAPK, TLR2 and NF-κB protein expression levels of observation group were lower
than those of control group (P<0.05). Conclusions: Sputum suction by bronchofiberoscope
combined with routine anti-infective therapy for patients with severe lung infection has positive
significance in improving patients’ lung function, inhibiting systemic inflammation and other
aspects. |
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| ISSN: | 1007-1237 1007-1237 |