Cytokines in the modulation of eosinophilia

• Main Authors: Faccioli Lúcia H, Vargaftig BB, Medeiros Alexandra I, Malheiros Adriana
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1997-01-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: eosinophils; helminth Parasites; inflammation; cytokines
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800015

In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection, and the interaction between these cytokines and IL-5 during infection. Finally we propose a new biological role for IL-5, at least in our model, as a modulator of IL-8 release and secretion.