Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

The rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from infections than from cancer in 2050 if current trends continue. To avoid this scenario, new classes of anti-infectives must urgently be developed. An...

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Main Authors:	Matthew B. Calvert, Varsha R. Jumde, Alexander Titz
Format:	Article
Language:	English
Published:	Beilstein-Institut 2018-10-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	antimicrobial resistance bacterial adhesins bacterial toxins pathoblockers quorum sensing
Online Access:	https://doi.org/10.3762/bjoc.14.239

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spelling	doaj-174a1e34626146cca24368047e57b4982021-02-02T00:30:41ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972018-10-011412607261710.3762/bjoc.14.2391860-5397-14-239Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infectionsMatthew B. Calvert0Varsha R. Jumde1Alexander Titz2Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, GermanyChemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, GermanyChemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, GermanyThe rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from infections than from cancer in 2050 if current trends continue. To avoid this scenario, new classes of anti-infectives must urgently be developed. Antibiotics with new modes of action are needed, but other concepts are also currently being pursued. Targeting bacterial virulence as a means of blocking pathogenicity is a promising new strategy for disarming pathogens. Furthermore, it is believed that this new approach is less susceptible towards resistance development. In this review, recent examples of anti-infective compounds acting on several types of bacterial targets, e.g., adhesins, toxins and bacterial communication, are described.https://doi.org/10.3762/bjoc.14.239antimicrobial resistancebacterial adhesinsbacterial toxinspathoblockersquorum sensing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matthew B. Calvert Varsha R. Jumde Alexander Titz
spellingShingle	Matthew B. Calvert Varsha R. Jumde Alexander Titz Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections Beilstein Journal of Organic Chemistry antimicrobial resistance bacterial adhesins bacterial toxins pathoblockers quorum sensing
author_facet	Matthew B. Calvert Varsha R. Jumde Alexander Titz
author_sort	Matthew B. Calvert
title	Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
title_short	Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
title_full	Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
title_fullStr	Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
title_full_unstemmed	Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
title_sort	pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2018-10-01
description	The rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from infections than from cancer in 2050 if current trends continue. To avoid this scenario, new classes of anti-infectives must urgently be developed. Antibiotics with new modes of action are needed, but other concepts are also currently being pursued. Targeting bacterial virulence as a means of blocking pathogenicity is a promising new strategy for disarming pathogens. Furthermore, it is believed that this new approach is less susceptible towards resistance development. In this review, recent examples of anti-infective compounds acting on several types of bacterial targets, e.g., adhesins, toxins and bacterial communication, are described.
topic	antimicrobial resistance bacterial adhesins bacterial toxins pathoblockers quorum sensing
url	https://doi.org/10.3762/bjoc.14.239
work_keys_str_mv	AT matthewbcalvert pathoblockersorantivirulencedrugsasanewoptionforthetreatmentofbacterialinfections AT varsharjumde pathoblockersorantivirulencedrugsasanewoptionforthetreatmentofbacterialinfections AT alexandertitz pathoblockersorantivirulencedrugsasanewoptionforthetreatmentofbacterialinfections
_version_	1724313685796585472

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

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