Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration

Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration

The fact that >99% of mitochondrial proteins are encoded by the nuclear genome and synthesised in the cytosol renders the process of mitochondrial protein import fundamental for normal organelle physiology. In addition to this, the nuclear genome comprises most of the proteins required for respir...

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Bibliographic Details
Main Authors: Hope I. Needs, Margherita Protasoni, Jeremy M. Henley, Julien Prudent, Ian Collinson, Gonçalo C. Pereira
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Life
Subjects:
protein import
mitochondrial dysfunction
respiratory complex assembly
supercomplexes
neurodegeneration
mitochondrial proteostasis
Online Access:https://www.mdpi.com/2075-1729/11/5/432

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