Revision of the concept of anti-angiogenesis and its applications in tumor treatment

Revision of the concept of anti-angiogenesis and its applications in tumor treatment

Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventi...

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Main Authors: Wen-Hui Yang, Jun Xu, Jian-Bing Mu, Jun Xie
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-03-01
Series:Chronic Diseases and Translational Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2095882X16300998
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spelling doaj-17226f6351f3463cb5a27d872c318c542021-03-02T09:26:27ZengKeAi Communications Co., Ltd.Chronic Diseases and Translational Medicine2095-882X2017-03-01313340Revision of the concept of anti-angiogenesis and its applications in tumor treatmentWen-Hui Yang0Jun Xu1Jian-Bing Mu2Jun Xie3Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Tumor Hospital of Shanxi Province, Taiyuan, Shanxi 030013, ChinaTumor Hospital of Shanxi Province, Taiyuan, Shanxi 030013, China; Corresponding author.Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USADepartment of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Corresponding author.Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer. Keywords: Anti-angiogenesis, Angiogenesis, Vascular endothelial growth factor, Cancerhttp://www.sciencedirect.com/science/article/pii/S2095882X16300998
collection DOAJ
language English
format Article
sources DOAJ
author Wen-Hui Yang
Jun Xu
Jian-Bing Mu
Jun Xie
spellingShingle Wen-Hui Yang
Jun Xu
Jian-Bing Mu
Jun Xie
Revision of the concept of anti-angiogenesis and its applications in tumor treatment
Chronic Diseases and Translational Medicine
author_facet Wen-Hui Yang
Jun Xu
Jian-Bing Mu
Jun Xie
author_sort Wen-Hui Yang
title Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_short Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_full Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_fullStr Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_full_unstemmed Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_sort revision of the concept of anti-angiogenesis and its applications in tumor treatment
publisher KeAi Communications Co., Ltd.
series Chronic Diseases and Translational Medicine
issn 2095-882X
publishDate 2017-03-01
description Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer. Keywords: Anti-angiogenesis, Angiogenesis, Vascular endothelial growth factor, Cancer
url http://www.sciencedirect.com/science/article/pii/S2095882X16300998
work_keys_str_mv AT wenhuiyang revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment
AT junxu revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment
AT jianbingmu revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment
AT junxie revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment
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