Regulation of myoblast differentiation by metabolic perturbations induced by metformin.
The metabolic perturbation caused by calorie restriction enhances muscle repair by playing a critical role in regulating satellite cell availability and activity in the muscles of young and old mice. To clarify the underlying mechanisms we asked whether myoblast replication and differentiation are a...
Main Authors: | Theodora Pavlidou, Marco Rosina, Claudia Fuoco, Giulia Gerini, Cesare Gargioli, Luisa Castagnoli, Gianni Cesareni |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5578649?pdf=render |
Similar Items
-
Metformin Delays Satellite Cell Activation and Maintains Quiescence
by: Theodora Pavlidou, et al.
Published: (2019-01-01) -
Metformin protects skeletal muscle from cardiotoxin induced degeneration.
by: Francesca Langone, et al.
Published: (2014-01-01) -
High-Dimensional Single-Cell Quantitative Profiling of Skeletal Muscle Cell Population Dynamics during Regeneration
by: Lucia Lisa Petrilli, et al.
Published: (2020-07-01) -
Myoblast Myogenic Differentiation but Not Fusion Process Is Inhibited via MyoD Tetraplex Interaction
by: Stefano Testa, et al.
Published: (2018-01-01) -
Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.
by: Alessandra Silvestri, et al.
Published: (2015-01-01)