Lack of an association of <it>miR-938 </it>SNP in IDDM10 with human type 1 diabetes

• Main Authors: Mi Xiaofan, He Hongzhi, Deng Yangxin, Levin Abert M, She Jin-Xiong, Mi Qing-Sheng, Zhou Li
• Format: Article
• Language: English
• Published: BMC 2011-10-01
• Series: Diabetology & Metabolic Syndrome
• Subjects: Type 1 diabetes; polymorphism; microRNAs
• Online Access: http://www.dmsjournal.com/content/3/1/27

<p>Abstract</p> <p>MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/<it>A</it>]CCC) of miRNA <it>miR-938 </it>and potentially alters <it>miR-938 </it>targets, including IL-16 and IL-17A. In an attempt to test whether <it>miR-938 </it>may be a susceptibility gene for IDDM10, we assessed the possible association of the <it>miR-938 </it>SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in <it>miR-938 </it>and type 1 diabetes.</p>