Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials

Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials

This work characterized the time‐course, circadian rhythm, and inherent variability in key cardiovascular variables (heart rate, corrected QT interval, and systolic and diastolic blood pressure) that are routinely collected as part of safety monitoring in phase I trials. Longitudinal data from 1,035...

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Bibliographic Details
Main Authors: Mukul Minocha, Hong Li, Yi‐Lin Chiu, David Carter, Ahmed A. Othman
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.12640

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