Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice.

Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice.

BACKGROUND:Mice with conditional, intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO) exhibit a complete block in chylomicron assembly together with lipid malabsorption. Young (8-10 week) Mttp-IKO mice have improved survival when subjected to a murine model of Pseudomo...

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Bibliographic Details
Main Authors: Zhe Liang, Yan Xie, Jessica A Dominguez, Elise R Breed, Benyam P Yoseph, Eileen M Burd, Alton B Farris, Nicholas O Davidson, Craig M Coopersmith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4092051?pdf=render

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