The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma

• Main Authors: Rouhollah Haghshenas, Mahvash Jafari, Aliasghar Ravasi, Mohammadreza Kordi, Neda Gilani, Mohammad Shariatzadeh, Mehdi Hedayati, Mostafa Rahimi
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2014-04-01
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: Endurance training; Food intake; High fat diet; Peptide hormones
• Online Access: http://ijbms.mums.ac.ir/pdf_2580_6d18467fe2598e3ef5154f6f47485792.html

Objective(s):Consumption of high-fat foods is one of the major causes of obesity. Physical exercise is a strategy used to counteract obesity. The aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (HFD) on appetite-regulating hormones in rat plasma. Materials and Methods:Twenty eight male Wistar rats were randomly divided into four groups: Control group with standard diet (CSD), endurance training with a standard diet (ESD), control group with high-fat diet (CHFD) and endurance training with high-fat diet (EHFD). Twenty-four hr after the last training session, the blood samples were obtained and analyzed for hormones levels. Results: The significant increased weight gain and food intake and decreased plasma nesfatin-1 and PYY3-36 levels were observed in CHFD group, while exercise under the HFD antagonized these effects. There were no significant changes in ghrelin, insulin and leptin levels in different groups. Conclusion: These results suggest that exercise can prevent fattening effect of HFD. Probably, performing exercise makes a reduction of food intake and weight gain in rat via the increase in nesfatin-1 and PYY levels. However, further studies are necessary to understand the exact mechanisms involved in this field.