Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model.

B-cell chronic lymphocytic leukemia (CLL) remains an incurable disease, and despite the improvement achieved by therapeutic regimes developed over the last years still a subset of patients face a rather poor prognosis and will eventually relapse and become refractory to therapy. The natural rotenoid...

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Main Authors: Nerea Rebolleda, Ignacio Losada-Fernandez, Gema Perez-Chacon, Raquel Castejon, Silvia Rosado, Marta Morado, Maria Teresa Vallejo-Cremades, Andrea Martinez, Juan A Vargas-Nuñez, Paloma Perez-Aciego
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4839760?pdf=render

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