Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus

The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restr...

Full description

Bibliographic Details
Main Authors:	Jolanta Dorota Torzecka, Joanna Narbutt, Anna Sysa-jedrzejowska, Maciej Borowiec, Anetta Ptasinska, Grzegorz Woszczek, Marek L. Kowalski
Format:	Article
Language:	English
Published:	Hindawi Limited 2003-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1080/09629350310001619735

id	doaj-16d11a236d134195be1d3aa7bfa63b78
record_format	Article
spelling	doaj-16d11a236d134195be1d3aa7bfa63b782020-11-25T01:06:48ZengHindawi LimitedMediators of Inflammation0962-93511466-18612003-01-0112530330710.1080/09629350310001619735Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigusJolanta Dorota Torzecka0Joanna Narbutt1Anna Sysa-jedrzejowska2Maciej Borowiec3Anetta Ptasinska4Grzegorz Woszczek5Marek L. Kowalski6Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandThe aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA-DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls.http://dx.doi.org/10.1080/09629350310001619735
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jolanta Dorota Torzecka Joanna Narbutt Anna Sysa-jedrzejowska Maciej Borowiec Anetta Ptasinska Grzegorz Woszczek Marek L. Kowalski
spellingShingle	Jolanta Dorota Torzecka Joanna Narbutt Anna Sysa-jedrzejowska Maciej Borowiec Anetta Ptasinska Grzegorz Woszczek Marek L. Kowalski Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus Mediators of Inflammation
author_facet	Jolanta Dorota Torzecka Joanna Narbutt Anna Sysa-jedrzejowska Maciej Borowiec Anetta Ptasinska Grzegorz Woszczek Marek L. Kowalski
author_sort	Jolanta Dorota Torzecka
title	Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
title_short	Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
title_full	Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
title_fullStr	Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
title_full_unstemmed	Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
title_sort	tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
publisher	Hindawi Limited
series	Mediators of Inflammation
issn	0962-9351 1466-1861
publishDate	2003-01-01
description	The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA-DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls.
url	http://dx.doi.org/10.1080/09629350310001619735
work_keys_str_mv	AT jolantadorotatorzecka tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT joannanarbutt tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT annasysajedrzejowska tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT maciejborowiec tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT anettaptasinska tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT grzegorzwoszczek tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT mareklkowalski tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus
_version_	1725188261223071744

Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus

Similar Items