De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth.

A central challenge of synthetic biology is to enable the growth of living systems using parts that are not derived from nature, but designed and synthesized in the laboratory. As an initial step toward achieving this goal, we probed the ability of a collection of >10(6) de novo designed proteins...

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Bibliographic Details
Main Authors: Michael A Fisher, Kara L McKinley, Luke H Bradley, Sara R Viola, Michael H Hecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3014984?pdf=render