Role of itraconazole in the management of aspergillosis in treated patients of pulmonary tuberculosis

• Main Authors: Gupta P, Vyas Aruna, Meena R, Khangarot S, Kanoongo Devesh, Jain S
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2005-01-01
• Series: Lung India
• Subjects: Aspergillosis; Aspergilloma; Chronic necrotizing pulmonary aspergillosis.
• Online Access: http://www.lungindia.com/article.asp?issn=0970-2113;year=2005;volume=22;issue=3;spage=81;epage=85;aulast=Gupta

Sputum/ bronchial washings of 445 patients with residual tubercular cavitation were subjected to smear and culture examination to isolate fungi. Patients suffering from aspergillosis were put on oral itraconazole daily for 6 months and monitored clinicoradiologically during and after therapy. About half of the patients of aspergilloma and 85% of the patients of chronic necrotizing pulmonary aspergillosis improved by 3 months of therapy. Nausea and headache observed during therapy in 8 and 4 patients respectively were mild and self limiting. Relapses were seen in 8 out of the 37 patients who had completed 6 months therapy and available for follow-up.