A miR-590/Acvr2a/Rad51b Axis Regulates DNA Damage Repair during mESC Proliferation

A miR-590/Acvr2a/Rad51b Axis Regulates DNA Damage Repair during mESC Proliferation

Embryonic stem cells (ESCs) enable rapid proliferation that also causes DNA damage. To maintain genomic stabilization during rapid proliferation, ESCs must have an efficient system to repress genotoxic stress. Here, we show that withdrawal of leukemia inhibitory factor (LIF), which maintains the sel...

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Bibliographic Details
Main Authors: Qidong Liu, Guiying Wang, Yafang Chen, Guoping Li, Dandan Yang, Jiuhong Kang
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114003282

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