Correlation of PECAM-1 gene C373G locus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia

• Main Authors: Mei Yan1, Ban-Ming Wu2, Li Zeng1
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-06-01
• Series: Journal of Hainan Medical University
• Subjects: Preeclampsia Platelet endothelial cell adhesion molecule-1 Gene polymorphism Endothelial injury
• Online Access: http://www.hnykdxxb.com/PDF/201711/26.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the correlation of PECAM-1 gene C373G locus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia. Methods: Pregnant women with preeclampsia and healthy pregnant women delivering in Obstetrics Department of Yibin Second People’s Hospital between May 2014 and September 2016 were selected and enrolled in PE group and control group respectively. Peripheral blood was collected to determine PECAM-1 gene C373G polymorphism as well as the contents of endothelial injury molecules sEng, PAR-1, sFlt-1 and ET-1; placenta tissue was collected to determine the contents of pathological damage molecules Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3. Results: PECAM-1 gene C373G locus GC and GG genotype constituent ratio and allele G constituent ratio in peripheral blood of PE group were significantly higher than those of control group while CC genotype constituent ratio and allele C constituent ratio were significantly lower than those of control group. sFlt-1, sEng, PAR-1 and ET-1 contents in serum as well as Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3 contents in placenta of PE group were significantly higher than those of control group; sFlt-1, sEng, PAR-1 and ET-1 contents in serum as well as Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3 contents in placenta of PE patients with PECAM-1 gene C373G locus GC and GG genotypes were higher than those of PE patients with CC genotype. Conclusion: Increased allele G in PECAM-1 gene C373G loci is closely correlated with endothelial injury and placental pathological damage in patients with preeclampsia.