Stimulation of IL-1β and IL-6 through NF-κB and sonic hedgehog-dependent pathways in mouse astrocytes by excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis

Stimulation of IL-1β and IL-6 through NF-κB and sonic hedgehog-dependent pathways in mouse astrocytes by excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis

Abstract Background Angiostrongylus cantonensis is an important causative agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans. Previous studies have shown that the Sonic hedgehog (Shh) signaling pathway may reduce cell apoptosis by inhibiting oxidative stress in A. canton...

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Bibliographic Details
Main Authors: Kuang-Yao Chen, Lian-Chen Wang
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Parasites & Vectors
Subjects:
Angiostrongylus cantonensis
Excretory/secretory products
Astrocytes
Sonic hedgehog signaling pathway
NF-κB
Cytokine
Online Access:http://link.springer.com/article/10.1186/s13071-017-2385-0

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