The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2
Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM a...
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Endocrinology Research Centre
2012-03-01
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| Series: | Сахарный диабет |
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| Online Access: | https://dia-endojournals.ru/dia/article/viewFile/5976/3735 |
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doaj-16a6f6d30a694c4f8d52b3756719cbc52021-06-02T19:26:19ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-03-01151313410.14341/2072-0351-59765934The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2Yulia Valer'evna Khasanova0Alsu Asatovna Nelaeva1Anna Borisovna Galkina2Irina Vasil'evna Medvedeva3Tyumen State Medical Academia, TyumenEndocrinological Dispensary of Tyumen, Tyumen; Tyumen State Medical Academia, TyumenTyumen State Medical Academia, TyumenTyumen State Medical Academia, TyumenAim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM.https://dia-endojournals.ru/dia/article/viewFile/5976/3735diabetes mellitus type 2diabetic nephropathychronic kidney diseasecoagulopathyiterleikin-6homocysteininflammation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yulia Valer'evna Khasanova Alsu Asatovna Nelaeva Anna Borisovna Galkina Irina Vasil'evna Medvedeva |
| spellingShingle |
Yulia Valer'evna Khasanova Alsu Asatovna Nelaeva Anna Borisovna Galkina Irina Vasil'evna Medvedeva The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 Сахарный диабет diabetes mellitus type 2 diabetic nephropathy chronic kidney disease coagulopathy iterleikin-6 homocystein inflammation |
| author_facet |
Yulia Valer'evna Khasanova Alsu Asatovna Nelaeva Anna Borisovna Galkina Irina Vasil'evna Medvedeva |
| author_sort |
Yulia Valer'evna Khasanova |
| title |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_short |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_full |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_fullStr |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_full_unstemmed |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_sort |
role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| publisher |
Endocrinology Research Centre |
| series |
Сахарный диабет |
| issn |
2072-0351 2072-0378 |
| publishDate |
2012-03-01 |
| description |
Aim.
To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).
Materials and methods.
A total of 240 patients with T2DM and DN were examined.
Results.
Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed.
Conclusion.
Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM. |
| topic |
diabetes mellitus type 2 diabetic nephropathy chronic kidney disease coagulopathy iterleikin-6 homocystein inflammation |
| url |
https://dia-endojournals.ru/dia/article/viewFile/5976/3735 |
| work_keys_str_mv |
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