Mediating Role of the Reward Network in the Relationship between the Dopamine Multilocus Genetic Profile and Depression

Mediating Role of the Reward Network in the Relationship between the Dopamine Multilocus Genetic Profile and Depression

Multiple genetic loci in the dopamine (DA) pathway have been associated with depression symptoms in patients with major depressive disorder (MDD). However, the neural mechanisms underlying the polygenic effects of the DA pathway on depression remain unclear. We used an imaging genetic approach to in...

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Bibliographic Details
Main Authors: Liang Gong, Cancan He, Yingying Yin, Hui Wang, Qing Ye, Feng Bai, Yonggui Yuan, Haisan Zhang, Luxian Lv, Hongxing Zhang, Zhijun Zhang, Chunming Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
depression
dopamine
imaging genetics
reward network
multilocus genetic profile
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00292/full

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