Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes

Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes

<p>Abstract</p> <p>Background</p> <p>Hepatitis C virus (HCV) infection may cause liver diseases of various severities ranging from primary acute infection to life-threatening diseases, such as cirrhosis or hepatocellular carcinoma with poor prognosis. According to clini...

Full description

Bibliographic Details
Main Authors:	Hsieh Ming-Ju, Lan Kuang-Ping, Liu Hao-Yu, Zhang Xiao-Zong, Lin Yaw-Feng, Chen Tzy-Yen, Chiou Hui-Ling
Format:	Article
Language:	English
Published:	BMC 2012-06-01
Series:	BMC Gastroenterology
Subjects:	Hepatitis C virus E2 envelope protein Type 2 diabetes mellitus Insulin resistance Insulin receptor substrate-1 (IRS-1) GSK3β
Online Access:	http://www.biomedcentral.com/1471-230X/12/74

Similar Items

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice
by: Steven E. Arnold, et al.
Published: (2014-07-01)

Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes
by: Yi Zhang, et al.
Published: (2020-01-01)

Differential Effects of Camel Milk on Insulin Receptor Signaling – Towards Understanding the Insulin-like Properties of Camel Milk
by: Abdulrasheed O Abdulrahman, et al.
Published: (2016-01-01)

LRP6 Knockdown Ameliorates Insulin Resistance via Modulation of Autophagy by Regulating GSK3β Signaling in Human LO2 Hepatocytes
by: Lei Li, et al.
Published: (2019-02-01)

Insulin receptor substrate 1 overexpression promotes survival of glioblastoma cells through AKT1 activation
by: Gokhan Gorgisen, et al.
Published: (2020-03-01)

Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice
by: Min Liu, et al.
Published: (2020-10-01)

Insulin stimulation of Akt/PKB phosphorylation in the placenta of preeclampsia patients
by: Gustavo Dias Ferreira, et al.

Chromium-insulin reduces insulin clearance and enhances insulin signaling by suppressing hepatic insulin-degrading enzyme and proteasome protein expression in KKAy mice
by: Zhong Q Wang, et al.
Published: (2014-07-01)

Association among insulin receptor substrate1 genetic polymorphism, sulfonylurea therapeutic efficacy, and insulin resistance in patients with type 2 diabetes mellitus
by: Ghada A Omar, et al.
Published: (2021-01-01)

The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
by: Fang, Youjia
Published: (2014)

The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins
by: Fumihiko eHakuno, et al.
Published: (2015-05-01)

Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3β
by: Zhao Wohua, et al.
Published: (2019-10-01)

Insulin receptor substrate-1 (IRS-1) associates with small nucleolar RNA which contributes to ribosome biogenesis
by: Atsufumi eOzoe, et al.
Published: (2014-03-01)

Lack of Association of Insulin Receptor Substrate Gene Polymorphisms with Obstructive Sleep Apnea Syndrome
by: Fulden Sarac, et al.
Published: (2013-12-01)

Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes
by: Danielsson, Anna
Published: (2007)

Modern Approaches to Determination of the Biological Activity of Insulin and its
by: T. A. Batuashvili, et al.
Published: (2019-06-01)

Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes
by: Renström, Frida
Published: (2007)

Cross-talk between insulin and serotonin signaling in the brain : Involvement of the PI3K/Akt pathway and behavioral consequences in models of insulin resistance
by: Papazoglou, Ioannis
Published: (2013)

The insulin receptor substrate 1 associates with phosphotyrosine phosphatase SHPTP2 in liver and muscle of rats
by: Lima M.H.M., et al.
Published: (1998-01-01)

Increase in Subcellular GSK-3 Clusters in Insulin- and Adrenaline-treated Differentiated Rat Skeletal Muscle Fibres
by: Katja Fink, et al.
Published: (2020-04-01)

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/−-IRS-1+/− Double Heterozygous (IR-IRS1dh) Mice
by: Andras Franko, et al.
Published: (2017-05-01)

Insulin Receptor Substrate 2 Controls Insulin-Mediated Vasoreactivity and Perivascular Adipose Tissue Function in Muscle
by: Alexander H. Turaihi, et al.
Published: (2018-03-01)

Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease
by: Daisuke Tanokashira, et al.
Published: (2019-01-01)

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
by: Liying Yang, et al.
Published: (2018-02-01)

Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer
by: Gokhan Gorgisen, et al.
Published: (2019-02-01)

D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes
by: Maria Magdalena Montt-Guevara, et al.
Published: (2021-03-01)

Dihydromyricetin Attenuates Metabolic Syndrome And Improves Insulin Sensitivity By Upregulating Insulin Receptor Substrate-1 (Y612) Tyrosine Phosphorylation In db/db Mice
by: He J, et al.
Published: (2019-11-01)

Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathways
by: Yiping Zhang, et al.
Published: (2018-09-01)

FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance
by: Oliver Stöhr, et al.
Published: (2021-03-01)

Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells
by: Xin Hu, et al.
Published: (2014-06-01)

IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance
by: Yousef AA, et al.
Published: (2018-09-01)

Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A
by: Kaiqing Ma, et al.
Published: (2016-09-01)

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling
by: Pingping Luo, et al.
Published: (2021-03-01)

The Relation of IGF-1 and Insulin Resistance in a Sample of Iraqi Obese Type 2 Diabetic Patients with Macrovascular Disease
by: Baghdad Science Journal
Published: (2012-12-01)

MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway
by: Wenqi Li, et al.
Published: (2021-06-01)

Insulin Receptor Substrate 1 Is Involved in the Phycocyanin-Mediated Antineoplastic Function of Non-Small Cell Lung Cancer Cells
by: Shuai Hao, et al.
Published: (2021-08-01)

Effects of Dioscorea esculenta and Eubacterium rectale on insulin receptor substrate 1 (Irs1) Expression in skeletal muscle and homeostatic model assessment-insulin resistance (HOMA-IR) in diabetic rats
by: . Sunarti, et al.
Published: (2017-01-01)

Modifying Effects of Glucose and Insulin/Insulin-Like Growth Factors on Colon Cancer Cells
by: Şeyda Berk, et al.
Published: (2021-07-01)

RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced Rats and Patients With Hyperuricemia
by: Chan Liu, et al.
Published: (2021-06-01)

p62‐mediated autophagy affects nutrition‐dependent insulin receptor substrate 1 dynamics in 3T3‐L1 preadipocytes
by: Hirobumi Igawa, et al.
Published: (2019-01-01)