KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation

KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation

Abstract Accumulating evidence supports the notion that epigenetic modifiers are abnormal in carcinogenesis and have a fundamental role in cancer progression. Among these aberrant epigenetic modifiers, the function of histone methyltransferase KMT2A in somatic tumors is not well known. By analyzing...

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Bibliographic Details
Main Authors: Yang Fang, Dan Zhang, Tingting Hu, Hongyan Zhao, Xuan Zhao, Zhefeng Lou, Yongshan He, Wenzheng Qin, Jianfu Xia, Xiaohua Zhang, Le‐chi Ye
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Cancer Medicine
Subjects:
cancer development
CTSZ
epigenetic modifier
KMT2A
Online Access:https://doi.org/10.1002/cam4.2226

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