Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2α signaling pathway in IPEC-J2 cells

Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2α signaling pathway in IPEC-J2 cells

Abstract Background Rotavirus (RV) is a major pathogen that causes severe gastroenteritis in infants and young animals. Endoplasmic reticulum (ER) stress and subsequent apoptosis play pivotal role in virus infection. However, the protective mechanisms of intestinal damage caused by RV are poorly def...

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Bibliographic Details
Main Authors: Ye Zhao, Ningming Hu, Qin Jiang, Li Zhu, Ming Zhang, Jun Jiang, Manyi Xiong, Mingxian Yang, Jiandong Yang, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Daiwen Chen
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Apoptosis
IPEC-J2
PERK-eIF2α
Rotavirus
Sodium butyrate
Online Access:https://doi.org/10.1186/s40104-021-00592-0

Internet

https://doi.org/10.1186/s40104-021-00592-0

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