Higher Activities of Hepatic Versus Splenic CD8+ T Cells in Responses to Adoptive T Cell Therapy and Vaccination of B6 Mice with MHC Class-1 Binding Antigen

Higher Activities of Hepatic Versus Splenic CD8+ T Cells in Responses to Adoptive T Cell Therapy and Vaccination of B6 Mice with MHC Class-1 Binding Antigen

The liver has unique microenvironment which is known to induce tolerance of cytolytic CD8+ T cells to hepatic and extra hepatic antigens, resulting in persistence of infection of the liver by the hepatitis B and C viruses. However, under some conditions, functional immune responses can be elicited...

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Bibliographic Details
Main Authors: Mohamed Labib Salem, Randa E. El Naggar, Sabry A. El Naggar, Maysa A. Mobasher, Mohamed H. Mahmoud, Gamal Badr
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2017-12-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
CD8 cyclophosphamide
Kupffer cells
Natural killer cells
Ovalbumin-specific OT-I
OVA
Poly(I
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1244

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