Are <i>Helicobacter pylori</i> Infection and Fucoidan Consumption Associated with Fucoidan Absorption?

• Main Authors: Makoto Tomori, Takeaki Nagamine, Masahiko Iha
• Format: Article
• Language: English
• Published: MDPI AG 2020-04-01
• Series: Marine Drugs
• Subjects: fucoidan; <i>Helicobacter pylori</i>; mozuku; <i>Cladosiphon okamuranus</i> Tokida; urinalysis
• Online Access: https://www.mdpi.com/1660-3397/18/5/235

We examined the associations of <i>Helicobacter pylori</i> and mozuku consumption with fucoidan absorption. Overall, 259 Japanese volunteers consumed 3 g fucoidan, and their urine samples were collected to measure fucoidan values and <i>H. pylori</i> titers before and 3, 6, and 9 h after fucoidan ingestion. Compared to the basal levels (3.7 ± 3.4 ng/mL), the urinary fucoidan values significantly increased 3, 6, and 9 h (15.3 ± 18.8, 24.4 ± 35.1, and 24.2 ± 35.2 ng/mL, respectively) after fucoidan ingestion. The basal fucoidan levels were significantly lower in <i>H. pylori</i>-negative subjects who rarely ate mozuku than in those who regularly consumed it. Regarding the ΔMax fucoidan value (highest value − basal value) in <i>H. pylori</i>-positive subjects who ate mozuku at least once a month, those aged ≥40 years exhibited significantly lower values than <40 years old. Among subjects ≥40 years old who regularly consumed mozuku, the ΔMax fucoidan value was significantly lower in <i>H. pylori</i>-positive subjects than in <i>H. pylori</i>-negative ones. In <i>H. pylori</i>-positive subjects who ate mozuku at least once monthly, basal fucoidan values displayed positive correlations with <i>H. pylori</i> titers and ΔMax fucoidan values in subjects <40 years old. No correlations were found in <i>H. pylori</i>-positive subjects who ate mozuku once every 2–3 months or less. Thus, fucoidan absorption is associated with <i>H. pylori</i> infection and frequency of mozuku consumption.