Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

<p>Abstract</p> <p>Background</p> <p>The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with <it>N-&l...

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Bibliographic Details
Main Authors: Eskew Jeffery D, Sadikot Takrima, Morales Pedro, Duren Alicia, Dunwiddie Irene, Swink Megan, Zhang Xiaoying, Hembruff Stacey, Donnelly Alison, Rajewski Roger A, Blagg Brian SJ, Manjarrez Jacob R, Matts Robert L, Holzbeierlein Jeffrey M, Vielhauer George A
Format: Article
Language:English
Published: BMC 2011-10-01
Series:BMC Cancer
Subjects:
Hsp90
prostate cancer
novobiocin
C-terminal inhibitors
N-terminal inhibitors
Online Access:http://www.biomedcentral.com/1471-2407/11/468

Internet

http://www.biomedcentral.com/1471-2407/11/468

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