Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to a...

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Bibliographic Details
Main Author:	Nam Ho Jeoung
Format:	Article
Language:	English
Published:	Korean Diabetes Association 2015-06-01
Series:	Diabetes & Metabolism Journal
Subjects:	Diabetes mellitus, type 2 Glucose metabolism Pyruvate dehydrogenase complex Pyruvate dehydrogenase kinase Pyruvate dehydrogenase kinase inhibitor Warberg effect
Online Access:	http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-188.pdf

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