Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH

Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH

Oral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. We brie...

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Main Authors: Guy Decaux, Fabrice Gankam Kengne, Bruno Couturier, Frédéric Vandergheynst, Wim Musch, Alain Soupart
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Journal of Clinical Medicine
Subjects:
hyponatremia
urea
V2 antagonist
ODS
SIADH
high ceiling diuretics
Online Access:http://www.mdpi.com/2077-0383/3/3/1043
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spelling doaj-163771a1627d4381841fc398c1477f6f2020-11-25T00:40:19ZengMDPI AGJournal of Clinical Medicine2077-03832014-09-01331043104910.3390/jcm3031043jcm3031043Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADHGuy Decaux0Fabrice Gankam Kengne1Bruno Couturier2Frédéric Vandergheynst3Wim Musch4Alain Soupart5Departments of Internal Medicine, Erasmus University Hospital, Route de Lennik, 808, Brussels B-1070, BelgiumDepartments of Nephrology, Erasmus University Hospital, Brussels B-1070, BelgiumDepartments of Internal Medicine, Erasmus University Hospital, Route de Lennik, 808, Brussels B-1070, BelgiumDepartments of Internal Medicine, Erasmus University Hospital, Route de Lennik, 808, Brussels B-1070, BelgiumDepartment of Internal Medicine, Bracops Hospital, Brussels B-1070, BelgiumDepartments of Internal Medicine, Erasmus University Hospital, Route de Lennik, 808, Brussels B-1070, BelgiumOral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. We briefly describe the indications of urea use in symptomatic and paucisymptomatic hyponatremic patients. Urea is a non-toxic, cheap product, and protects against osmotic demyelinating syndrome (ODS) in experimental studies. Prospective studies showing the benefit to treat mild chronic hyponatremia due to SIADH and comparing water restriction, urea, high ceiling diuretics, and antivasopressin antagonist antagonist should be done.http://www.mdpi.com/2077-0383/3/3/1043hyponatremiaureaV2 antagonistODSSIADHhigh ceiling diuretics
collection DOAJ
language English
format Article
sources DOAJ
author Guy Decaux
Fabrice Gankam Kengne
Bruno Couturier
Frédéric Vandergheynst
Wim Musch
Alain Soupart
spellingShingle Guy Decaux
Fabrice Gankam Kengne
Bruno Couturier
Frédéric Vandergheynst
Wim Musch
Alain Soupart
Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH
Journal of Clinical Medicine
hyponatremia
urea
V2 antagonist
ODS
SIADH
high ceiling diuretics
author_facet Guy Decaux
Fabrice Gankam Kengne
Bruno Couturier
Frédéric Vandergheynst
Wim Musch
Alain Soupart
author_sort Guy Decaux
title Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH
title_short Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH
title_full Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH
title_fullStr Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH
title_full_unstemmed Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely Symptomatic and Mild Chronic Hyponatremia Related to SIADH
title_sort actual therapeutic indication of an old drug: urea for treatment of severely symptomatic and mild chronic hyponatremia related to siadh
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2014-09-01
description Oral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. We briefly describe the indications of urea use in symptomatic and paucisymptomatic hyponatremic patients. Urea is a non-toxic, cheap product, and protects against osmotic demyelinating syndrome (ODS) in experimental studies. Prospective studies showing the benefit to treat mild chronic hyponatremia due to SIADH and comparing water restriction, urea, high ceiling diuretics, and antivasopressin antagonist antagonist should be done.
topic hyponatremia
urea
V2 antagonist
ODS
SIADH
high ceiling diuretics
url http://www.mdpi.com/2077-0383/3/3/1043
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