Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity

Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity

Summary: The tissue inhibitor of metalloproteinases 2 (TIMP-2) is a specific endogenous inhibitor of matrix metalloproteinase 2 (MMP-2), which is a key enzyme that degrades the extracellular matrix and promotes tumor cell invasion. Although the TIMP-2:MMP-2 complex controls proteolysis, the signalin...

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Bibliographic Details
Main Authors: Javier Sánchez-Pozo, Alexander J. Baker-Williams, Mark R. Woodford, Renee Bullard, Beiyang Wei, Mehdi Mollapour, William G. Stetler-Stevenson, Gennady Bratslavsky, Dimitra Bourboulia
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300087

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http://www.sciencedirect.com/science/article/pii/S2589004218300087

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