ER and PI3K Pathway Activity in Primary ER Positive Breast Cancer Is Associated with Progression-Free Survival of Metastatic Patients under First-Line Tamoxifen

ER and PI3K Pathway Activity in Primary ER Positive Breast Cancer Is Associated with Progression-Free Survival of Metastatic Patients under First-Line Tamoxifen

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Estrogen receptor positive (ER+) breast cancer patients are eligible for hormonal treatment, but only around half respond. A test with higher specificity for prediction of endocrine therapy response is needed to avoid hormonal overtreatment and to enable selection of alternative treatments. A novel...

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Bibliographic Details
Main Authors: Anieta M. Sieuwerts, M\u00e1rcia A. Inda, Marcel Smid, Henk van Ooijen, Anja van de Stolpe, John W. M. Martens, Wim F. J. Verhaegh
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
signaling pathway
functional activity
metastasis
progression-free survival
tamoxifen
treatment response
Online Access:http://https:\/\/www.mdpi.com\/2072-6694\/12\/4\/802
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