A maladaptive role for EP4 receptors in mouse mesangial cells.

Roles of the prostaglandin E2 E-prostanoid 4 receptor (EP4) on extracellular matrix (ECM) accumulation induced by TGF-β1 in mouse glomerular mesangial cells (GMCs) remain unknown. Previously, we have identified that TGF-β1 stimulates the expression of FN and Col I in mouse GMCs. Here we asked whethe...

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Bibliographic Details
Main Authors: Guang-xia Yang, Yu-yin Xu, Ya-ping Fan, Jing Wang, Xiao-lan Chen, Yi-de Zhang, Jian-hua Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4133176?pdf=render