Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli

Resistance to one antibiotic can in some cases increase susceptibility to other antibiotics. Here, Podnecky et al. study these collateral responses in E. coli clinical isolates and show that efflux-related resistance mechanisms and relative fitness of the strains are principal contributors to this p...

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Bibliographic Details
Main Authors: Nicole L. Podnecky, Elizabeth G. A. Fredheim, Julia Kloos, Vidar Sørum, Raul Primicerio, Adam P. Roberts, Daniel E. Rozen, Ørjan Samuelsen, Pål J. Johnsen
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06143-y