Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?

Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?

A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent...

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Main Authors: Shanshan An MS, Sirui Yan BS, Ying Zhang MS, Huan Xu BS, Tao Gan PhD, Qiuyun Liu PhD
Format: Article
Language:English
Published: SAGE Publishing 2020-08-01
Series:Cancer Control
Online Access:https://doi.org/10.1177/1073274820954453
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spelling doaj-1614e03af934487e9fbca40e27d6939a2020-11-25T03:39:56ZengSAGE PublishingCancer Control1073-27482020-08-012710.1177/1073274820954453Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?Shanshan An MS0Sirui Yan BS1Ying Zhang MS2Huan Xu BS3Tao Gan PhD4Qiuyun Liu PhD5 School of Life Sciences, , Guangzhou, China School of Life Sciences, , Guangzhou, China , Guangzhou, China School of Electronic Information and Automation, , Guilin, Guangxi, China School of Basic Medicine, , Jiangxi, China School of Life Sciences, , Guangzhou, ChinaA tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level.https://doi.org/10.1177/1073274820954453
collection DOAJ
language English
format Article
sources DOAJ
author Shanshan An MS
Sirui Yan BS
Ying Zhang MS
Huan Xu BS
Tao Gan PhD
Qiuyun Liu PhD
spellingShingle Shanshan An MS
Sirui Yan BS
Ying Zhang MS
Huan Xu BS
Tao Gan PhD
Qiuyun Liu PhD
Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
Cancer Control
author_facet Shanshan An MS
Sirui Yan BS
Ying Zhang MS
Huan Xu BS
Tao Gan PhD
Qiuyun Liu PhD
author_sort Shanshan An MS
title Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
title_short Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
title_full Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
title_fullStr Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
title_full_unstemmed Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
title_sort is it possible to establish a tumor-suppressive microenvironment with glycine and valine supplement?
publisher SAGE Publishing
series Cancer Control
issn 1073-2748
publishDate 2020-08-01
description A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level.
url https://doi.org/10.1177/1073274820954453
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