A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B

A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B

Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity have been reported in the treatment of HIV patients. Even more recently, very few cases of Fan...

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Main Authors: Dongwoo Kim, Jongjin Lee, Dae-ha Kim, Kyuho Kang, Sang Jun Suh, Young Kul Jung, Hyung Joon Yim
Format: Article
Language:English
Published: Jin Publishing & Printing Co. 2016-12-01
Series:The Korean Journal of Gastroenterology
Subjects:
Tenofovir
Hepatitis B virus
Fanconi syndrome
Kidney tubules
proximal
Osteomalacia
Online Access:http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2016.68.6.317
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spelling doaj-160e1f051ce3441bb84123c8d73f231b2020-11-24T20:50:03ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922016-12-0168631732010.4166/kjg.2016.68.6.317kjg.2016.68.6.317A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis BDongwoo Kim0Jongjin Lee1Dae-ha Kim2Kyuho Kang3Sang Jun Suh4Young Kul Jung5Hyung Joon Yim6Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreTenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity have been reported in the treatment of HIV patients. Even more recently, very few cases of Fanconi syndrome associated with tenofovir therapy in HBV monoinfection have been reported. Herein, we report a case of a 47-year-old male with an HBV monoinfection, who developed Fanconi syndrome and a secondary osteomalacia with multiple bone pain. After TDF withdrawal and supplementation of calcitriol, his renal function was reverted. Although the overall risk of TDF-associated nephrotoxicity is very low, both glomerular and tubular function should be monitored in patients undergoing TDF treatment. (Korean J Gastroenterol 2016;68:317-320)http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2016.68.6.317TenofovirHepatitis B virusFanconi syndromeKidney tubulesproximalOsteomalacia
collection DOAJ
language English
format Article
sources DOAJ
author Dongwoo Kim
Jongjin Lee
Dae-ha Kim
Kyuho Kang
Sang Jun Suh
Young Kul Jung
Hyung Joon Yim
spellingShingle Dongwoo Kim
Jongjin Lee
Dae-ha Kim
Kyuho Kang
Sang Jun Suh
Young Kul Jung
Hyung Joon Yim
A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
The Korean Journal of Gastroenterology
Tenofovir
Hepatitis B virus
Fanconi syndrome
Kidney tubules
proximal
Osteomalacia
author_facet Dongwoo Kim
Jongjin Lee
Dae-ha Kim
Kyuho Kang
Sang Jun Suh
Young Kul Jung
Hyung Joon Yim
author_sort Dongwoo Kim
title A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
title_short A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
title_full A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
title_fullStr A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
title_full_unstemmed A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
title_sort case of tenofovir-associated fanconi syndrome in patient with chronic hepatitis b
publisher Jin Publishing & Printing Co.
series The Korean Journal of Gastroenterology
issn 1598-9992
publishDate 2016-12-01
description Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity have been reported in the treatment of HIV patients. Even more recently, very few cases of Fanconi syndrome associated with tenofovir therapy in HBV monoinfection have been reported. Herein, we report a case of a 47-year-old male with an HBV monoinfection, who developed Fanconi syndrome and a secondary osteomalacia with multiple bone pain. After TDF withdrawal and supplementation of calcitriol, his renal function was reverted. Although the overall risk of TDF-associated nephrotoxicity is very low, both glomerular and tubular function should be monitored in patients undergoing TDF treatment. (Korean J Gastroenterol 2016;68:317-320)
topic Tenofovir
Hepatitis B virus
Fanconi syndrome
Kidney tubules
proximal
Osteomalacia
url http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2016.68.6.317
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