Main protease inhibitors and drug surface hotspots for the treatment of COVID-19: A drug repurposing and molecular docking approach

Main protease inhibitors and drug surface hotspots for the treatment of COVID-19: A drug repurposing and molecular docking approach

Here, drug repurposing and molecular docking were employed to screen approved MPP inhibitors and their derivatives to suggest a specific therapeutic agent for the treatment of COVID-19. The approved MPP inhibitors against HIV and HCV were prioritized, while RNA dependent RNA Polymerase (RdRp) inhibi...

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Bibliographic Details
Main Authors: Mahmudul Hasan, Md. Sorwer Alam Parvez, Kazi Faizul Azim, Md. Abdus Shukur Imran, Topu Raihan, Airin Gulshan, Samuel Muhit, Rubaiat Nazneen Akhand, Syed Sayeem Uddin Ahmed, Md Bashir Uddin
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Main protease protein (MPP) inhibitors
SARS-CoV-2
COVID-19
Drug repurposing
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221005242

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