An unusual association of renal cell carcinoma and renal malakoplakia with focal segmental glomerulosclerosis in an elderly patient

• Main Authors: M Vijayan, P Koshy, R Parthasarathy, M Mathew, G Abraham
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Indian Journal of Nephrology
• Subjects: Focal segmental glomerulosclerosis; malakoplakia; renal cell carcinoma
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2018;volume=28;issue=6;spage=485;epage=487;aulast=Vijayan

The association of malignancy and glomerulonephritis may be missed, especially in elderly patients. Here, we report a case of eosinophilic variant of renal cell carcinoma and renal parenchymal malakoplakia discovered on renal biopsy in a patient with steroid-dependent nephrotic syndrome. The presence of malakoplakia in our biopsy was probably due to systemic steroid therapy for glomerulonephritis, presence of concomitant asymptomatic urinary tract infection, and/or history of diabetes mellitus. The patient had remission of proteinuria following laparoscopic removal of the tumor, indicating probable remission of glomerulonephritis.