Redox-mediated bypass of restriction point via skipping of G1pm

• Main Authors: Greene James J, Hoffman Arnold, Spetner Lee M, Burke Michael
• Format: Article
• Language: English
• Published: BMC 2006-07-01
• Series: Theoretical Biology and Medical Modelling
• Online Access: http://www.tbiomed.com/content/3/1/26

<p>Abstract</p> <p>Background</p> <p>It is well known that cancer cells bypass the restriction point, R, and undergo uncontrolled cell proliferation.</p> <p>Hypothesis and evidence</p> <p>We suggest here that fibrosarcoma cells enter G_1psdirectly from M, skipping G_1pm, <it/>hence <it/>bypassing R, in response to redox modulation. Evidence is presented from the published literature that demonstrate a shortening of the cycle period of transformed fibroblasts (SV-3T3) compared to the nontransformed 3T3 fibroblasts, corresponding to the duration of G_1pmin the 3T3 fibroblasts. Evidence is also presented that demonstrate that redox modulation can induce the CUA-4 fibroblasts to bypass R, resulting in a cycle period closely corresponding to the cycle period of fibrosarcoma cells (HT1080).</p> <p>Conclusion</p> <p>The evidence supports our hypothesis that a low internal redox potential can cause fibrosarcoma cells to skip the G_1pmphase of the cell cycle.</p>