Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells

Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells

Previous studies suggest that the presence of antigen-specific polyfunctional T cells is correlated with improved pathogen clearance, disease control, and clinical outcomes; however, the molecular mechanisms responsible for the generation, function, and survival of polyfunctional T cells remain unkn...

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Bibliographic Details
Main Authors: Zachary R. Healy, Kent J. Weinhold, David M. Murdoch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
polyfunctional T cells
CMV
RNAseq
fixation
permeabilization
RNA quality
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01859/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01859/full

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