Vitamin K2-Dependent GGCX and MGP Are Required for Homeostatic Calcium Regulation of Sperm Maturation

Vitamin K2-Dependent GGCX and MGP Are Required for Homeostatic Calcium Regulation of Sperm Maturation

Summary: A low-calcium microenvironment is essential for spermatozoa to mature in the epididymis; however, it remains unclear how dysregulation of epididymal luminal calcium is associated with male infertility. Using a warfarin-induced vitamin K2 deficiency rat model, we found that vitamin-K-depende...

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Bibliographic Details
Main Authors: He Ma, Bao Li Zhang, Bao Ying Liu, Shuo Shi, Da Yuan Gao, Tian Cheng Zhang, Hui Juan Shi, Zhen Li, Winnie Waichi Shum
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219300963

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http://www.sciencedirect.com/science/article/pii/S2589004219300963

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